Job Description

Our 20-plus years of RNAi experience together with our validated mRNAi GOLD platform make us a partner of choice for pharmaceutical companies looking to access the benefits of the siRNA and add this revolutionary modality to their discovery pipeline. As pioneers in the design and development of siRNAs (short interfering RNAs), Silence Therapeutics is advancing a new generation of medicines to potentially address the needs of patients who have limited or inadequate treatment options. Our mission is to use our technology to create a new generation of therapeutics that can improve patient outcomes and, in the process, build shareholder value. We are developing a deep pipeline of innovative siRNAs based on our mRNAi GOLD platform for diseases with a genetic basis. The depth and versatility of our liver-targeting technology gives us the opportunity to address a wide range of conditions in virtually any therapeutic area. Our wholly-owned pipeline is currently focused in three therapeutic areas of high unmet need: hematology, cardiovascular, and rare diseases. Role Purpose We are seeking a knowledgeable and motivated Medical Science Liaison (MSL) to join our dynamic team. Reporting directly to the Chief Medical Officer, this is an exciting opportunity to lead the build-out of the MSL function. This role will act as a scientific expert and strategic partner between our company and the healthcare community. It will engage with key opinion leaders (KOLs), clinical investigational sites, provide clinical and scientific support, and facilitate the exchange of information about our products in development across therapeutic areas. Key Responsibilities As the first member of the team, this role will work closely with the Chief Medical Officer to build out the MSL/medical affairs function. It is a remote position that will have nationwide responsibility. Build and maintain relationships with healthcare professionals and KOLs to provide expert scientific and clinical insights. Identify key KOLs at the local, regional and national levels. Deliver accurate and relevant information regarding the company’s assets in development, and targeted therapeutic areas to healthcare professionals and internal stakeholders. Assist in identifying and engaging potential clinical trial sites and investigators; provide support during study initiation and execution. Collaborate with patient advocacy organizations to understand patient needs, gather feedback, and support initiatives that enhance patient care. Conduct training sessions for internal teams on scientific data and product knowledge; support peers with medical insights. Gather insights and market intelligence from healthcare professionals to inform company strategy, product development, and marketing initiatives. Support development of advisory boards and key medical education initiatives as needed, reporting back and summarizing key discussions and takeaways for internal teams in concert with the clinical science teams. Respond to scientific inquiries from HCPs utilizing approved materials and resources. Ensure all activities comply with industry regulations and company policies; maintain up-to-date knowledge of industry guidelines. Person Specification A Doctorate level scientific degree (PhD, PharmD, MD) is required. 5-10 years of relevant scientific experience or clinical experience, with at least 3 years of experience in the biotech or pharmaceutical industry, preferably in medical affairs. Experience in haematological diseases would be advantageous. Strong communication, interpersonal and presentation skills. Ability to analyze and interpret complex scientific data. Proficiency in building relationships with KOLs and healthcare professionals. Knowledge of pharmaceutical regulations and compliance. Must hold a valid US driver’s license and be able to travel. Essential Physical Requirements Ability to view video display terminal images Ability to operate a computer keyboard and telephone. Ability to sit for extended periods of time – up to four (4) hours at a time. Ability to travel via automobile and/or airplane. Ability to lift, tug, pull up to fifteen (15) pounds. To be considered for this position, you must apply and meet the requirements of this opportunity. NOTE: This job description is not intended to be all-inclusive. Employee may perform other related duties as negotiated to meet the on-going needs of the organisation. Silence Therapeutics is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex, gender identity, sexual orientation, national origin, disability, protected veteran status or any other characteristic protected by local, state or federal laws, rules or regulations. #J-18808-Ljbffr Silence Therapeutics plc

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